CD28

CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Th2 Differentiation Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.

CD28 Molecule

CD28 Molecule; CD28 Antigen; Tp44; T-Cell-Specific Surface Glycoprotein CD28; T-Cell-Specific Surface Glycoprotein; CD28 Antigen (Tp44);

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).
Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Apoptotic signaling pathway Source: Ensembl
Cell surface receptor signaling pathway Source: UniProtKB
Humoral immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative thymic T cell selection Source: Ensembl
Positive regulation of alpha-beta T cell proliferation Source: Ensembl
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of inflammatory response to antigenic stimulus Source: Ensembl
Positive regulation of interleukin-10 production Source: UniProtKB
Positive regulation of interleukin-2 production Source: UniProtKB
Positive regulation of interleukin-4 production Source: UniProtKB
Positive regulation of isotype switching to IgG isotypes Source: Ensembl
Positive regulation of mitotic nuclear division Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
Positive regulation of protein kinase B signaling Source: Reactome
Positive regulation of T cell proliferation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of translation Source: UniProtKB
Positive regulation of viral genome replication Source: UniProtKB
Regulation of defense response to virus by virus Source: Reactome
Regulation of regulatory T cell differentiation Source: Ensembl
Regulatory T cell differentiation Source: BHF-UCL
T cell activation Source: BHF-UCL
T cell costimulation Source: GO_Central
T cell receptor signaling pathway Source: GO_Central

Membrane
Isoform 3: Cell surface

Extracellular: 19-152
Helical: 153-179
Cytoplasmic: 180-220

CD40LG induces tyrosine phosphorylation of isoform 3.