CD200R1

CD200R1 (CD200 Receptor 1) is a Protein Coding gene. Diseases associated with CD200R1 include Primary Hypertrophic Osteoarthropathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CD200R1L.

CD200 Receptor 1

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Heterotypic cell-cell adhesion Source: ARUK-UCL
Intracellular signal transduction Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of macrophage migration Source: ARUK-UCL
Negative regulation of neuroinflammatory response Source: ARUK-UCL
Negative regulation of neuron death Source: ARUK-UCL
Negative regulation of T cell migration Source: ARUK-UCL
Regulation of immune response Source: Reactome
Regulation of neuroinflammatory response Source: ARUK-UCL
Signal transduction Source: ARUK-UCL
Viral process Source: UniProtKB-KW

Isoform 1&4: Cell membrane
Isoform 2&3: Secreted

Extracellular: 29-243
Helical: 244-264
Cytoplasmic: 265-325

The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.