CD14

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Croup. Among its related pathways are Bacterial infections in CF airways and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

CD14 Molecule

CD14 Molecule; CD14 Antigen; Myeloid Cell-Specific Leucine-Rich Glycoprotein;

Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655).
In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655, PubMed:22265692).
Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135).
Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- (PubMed:23880187).

Apoptotic process Source: ProtInc
Apoptotic signaling pathway Source: Reactome
Cell surface receptor signaling pathway Source: ProtInc
Cellular response to diacyl bacterial lipopeptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: MGI
Cellular response to lipoteichoic acid Source: MGI
Cellular response to molecule of bacterial origin Source: CAFA
Cellular response to triacyl bacterial lipopeptide Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: Reactome
Inflammatory response Source: GO_Central
Innate immune response Source: UniProtKB-KW
Lipopolysaccharide-mediated signaling pathway Source: GO_Central
MyD88-dependent toll-like receptor signaling pathway Source: Reactome
MyD88-independent toll-like receptor signaling pathway Source: Reactome
Necroptotic process Source: Reactome
Negative regulation of MyD88-independent toll-like receptor signaling pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Phagocytosis Source: ProtInc
Positive regulation of endocytosis Source: Ensembl
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of interleukin-8 production Source: CAFA
Positive regulation of NIK/NF-kappaB signaling Source: AgBase
Positive regulation of tumor necrosis factor production Source: AgBase
Positive regulation of type I interferon production Source: GO_Central
Receptor-mediated endocytosis Source: Ensembl
Response to electrical stimulus Source: Ensembl
Response to ethanol Source: Ensembl
Response to heat Source: Ensembl
Response to magnesium ion Source: Ensembl
Response to tumor necrosis factor Source: Ensembl
Toll-like receptor 4 signaling pathway Source: UniProtKB
Toll-like receptor signaling pathway Source: Reactome
Toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
Toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: Reactome

Golgi apparatus; Secreted; Cell membrane; Membrane raft. Secreted forms may arise by cleavage of the GPI anchor.

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.