CCR4

CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.

Full Name

C-C Motif Chemokine Receptor 4

Function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Biological Process

Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Homeostasis of number of cells Source: Ensembl
Immune response Source: GO_Central
Inflammatory response Source: ProtInc
Neuron migration Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of positive chemotaxis Source: Ensembl
Response to antibiotic Source: Ensembl
Response to bacterium Source: Ensembl
Response to radiation Source: Ensembl
Tolerance induction Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-39
Helical: 40-67
Cytoplasmic: 68-77
Helical: 78-98
Extracellular: 99-111
Helical: 112-133
Cytoplasmic: 134-150
Helical: 151-175
Extracellular: 176-206
Helical: 207-226
Cytoplasmic: 227-242
Helical: 243-267
Extracellular: 268-284
Helical: 285-308
Cytoplasmic: 309-360

PTM

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.