CALM2

CALM2 (Calmodulin 2) is a Protein Coding gene. Diseases associated with CALM2 include Long Qt Syndrome 15 and Long Qt Syndrome 1. Among its related pathways are RET signaling and N-cadherin signaling events. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CALM3.

calmodulin 2 (phosphorylase kinase, delta)

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).
Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752).
Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).

Detection of calcium ion Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
Positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Positive regulation of protein autophosphorylation Source: BHF-UCL
Positive regulation of protein dephosphorylation Source: BHF-UCL
Positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Regulation of cytokinesis Source: UniProtKB
Regulation of heart rate Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of ryanodine-sensitive calcium-release channel activity Source: GO_Central
Response to calcium ion Source: BHF-UCL
Substantia nigra development Source: UniProtKB

Spindle; Spindle pole; Centrosome. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Long QT syndrome 15 (LQT15): A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Ubiquitination results in a strongly decreased activity.
Phosphorylation results in a decreased activity.