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BIRC3

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Full Name
Baculoviral IAP Repeat Containing 3
Function
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
I-kappaB kinase/NF-kappaB signaling Source: Reactome
MyD88-independent toll-like receptor signaling pathway Source: Reactome
Negative regulation of apoptotic process Source: GO_Central
Negative regulation of necroptotic process Source: GO_Central
NIK/NF-kappaB signaling Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of protein ubiquitination Source: UniProtKB
Protein deubiquitination Source: Reactome
Regulation of apoptotic process Source: UniProtKB
Regulation of cell cycle Source: GO_Central
Regulation of cysteine-type endopeptidase activity Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Regulation of necroptotic process Source: UniProtKB
Regulation of nucleotide-binding oligomerization domain containing signaling pathway Source: UniProtKB
Regulation of RIG-I signaling pathway Source: UniProtKB
Regulation of toll-like receptor signaling pathway Source: UniProtKB
Regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
TRIF-dependent toll-like receptor signaling pathway Source: Reactome
Tumor necrosis factor-mediated signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
PTM
Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

Anti-BIRC3 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYC-0578
Application*: WB
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0607
Application*: WB, IF
Target: BIRC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-0599
Application*: IP, IF, IH, IC, WB
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G7
Application*: WB
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10E9
Application*: WB, IP
Target: BIRC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG391
Application*: WB, IP
Target: BIRC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 58C7
Application*: WB, IP
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B2
Application*: WB
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 1F12-E5-G12
Application*: WB
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 16E63
Application*: WB, IHC
Target: BIRC3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 315304
Application*: WB, IH
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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