ATP2B4

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

ATPase, Ca++ transporting, plasma membrane 4

Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416).
By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity).

Calcium ion export Source: ARUK-UCL
Calcium ion import across plasma membrane Source: BHF-UCL
Calcium ion transmembrane import into cytosol Source: BHF-UCL
Calcium ion transmembrane transport Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Cellular response to acetylcholine Source: UniProtKB
Cellular response to epinephrine stimulus Source: BHF-UCL
Flagellated sperm motility Source: UniProtKB
Hippocampus development Source: Ensembl
Ion transmembrane transport Source: Reactome
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Source: BHF-UCL
Negative regulation of angiogenesis Source: ARUK-UCL
Negative regulation of arginine catabolic process Source: BHF-UCL
Negative regulation of blood vessel endothelial cell migration Source: ARUK-UCL
Negative regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Negative regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
Negative regulation of cellular response to vascular endothelial growth factor stimulus Source: ARUK-UCL
Negative regulation of citrulline biosynthetic process Source: BHF-UCL
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of nitric oxide biosynthetic process Source: BHF-UCL
Negative regulation of nitric oxide mediated signal transduction Source: BHF-UCL
Negative regulation of nitric-oxide synthase activity Source: BHF-UCL
Negative regulation of peptidyl-cysteine S-nitrosylation Source: BHF-UCL
Negative regulation of the force of heart contraction Source: BHF-UCL
Neural retina development Source: Ensembl
Positive regulation of cAMP-dependent protein kinase activity Source: BHF-UCL
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of protein localization to plasma membrane Source: ARUK-UCL
Regulation of cardiac conduction Source: Reactome
Regulation of cell cycle G1/S phase transition Source: CACAO
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of sodium ion transmembrane transport Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: BHF-UCL
Response to hydrostatic pressure Source: BHF-UCL
Spermatogenesis Source: Ensembl
Transport across blood-brain barrier Source: ARUK-UCL
Urinary bladder smooth muscle contraction Source: UniProtKB

Cell membrane; Flagellum membrane

Cytoplasmic: 1-92 aa
Helical: 93-113 aa
Extracellular: 114-150 aa
Helical: 151-171 aa
Cytoplasmic: 172-356 aa
Helical: 357-376 aa
Extracellular: 377-409 aa
Helical: 410-427 aa
Cytoplasmic: 428-840 aa
Helical: 841-860 aa
Extracellular: 861-870 aa
Helical: 871-891 aa
Cytoplasmic: 892-911 aa
Helical: 912-934 aa
Extracellular: 935-952 aa
Helical: 953-974 aa
Cytoplasmic: 975-993 aa
Helical: 994-1015 aa
Extracellular: 1016-1025 aa
Helical: 1026-1047 aa
Cytoplasmic: 1048-1241 aa