ADCY1

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Adenylate Cyclase 1

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

Activation of adenylate cyclase activity
Activation of protein kinase A activity
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Axonogenesis
Brain development
cAMP biosynthetic process
cAMP-mediated signaling
Cellular response to calcium ion
Cellular response to forskolin
Cellular response to glucagon stimulus
Circadian rhythm
G protein-coupled receptor signaling pathway
Long-term memory
Negative regulation of inflammatory response to antigenic stimulus
Neuroinflammatory response
Positive regulation of CREB transcription factor activity
Positive regulation of long-term synaptic potentiation
Regulation of circadian rhythm
Regulation of synaptic vesicle exocytosis
Renal water homeostasis
Response to drug
Response to lithium ion

Cell membrane; Cytoplasm; Membrane. Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia.

Deafness, autosomal recessive, 44 (DFNB44): A form of non-syndromic deafness characterized by prelingual profound hearing loss affecting all frequencies.

N-glycosylated.