ACE

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Angiotensin I Converting Enzyme

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

Amyloid-beta metabolic process
Angiotensin maturation
Antigen processing and presentation of peptide antigen via MHC class I
Arachidonic acid secretion
Blood vessel diameter maintenance
Blood vessel remodeling
Cell proliferation in bone marrow
Heart contraction
Hematopoietic stem cell differentiation
Hormone catabolic process
Kidney development
Mononuclear cell proliferation
Negative regulation of gap junction assembly
Negative regulation of gene expression
Negative regulation of protein binding
Neutrophil mediated immunity
Peptide catabolic process
Positive regulation of peptidyl-cysteine S-nitrosylation
Positive regulation of peptidyl-tyrosine autophosphorylation
Positive regulation of protein binding
Positive regulation of protein tyrosine kinase activity
Positive regulation of systemic arterial blood pressure
Posttranscriptional regulation of gene expression
Proteolysis
Regulation of angiotensin metabolic process
Regulation of blood pressure
Regulation of hematopoietic stem cell proliferation
Regulation of renal output by angiotensin
Regulation of smooth muscle cell migration
Regulation of systemic arterial blood pressure by renin-angiotensin
Regulation of vasoconstriction
Spermatogenesis

Secreted; Cell membrane; Cytoplasm. Detected in both cell membrane and cytoplasm in neurons.

A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Extracellular: 30-1256 aa
Helical: 1257-1277 aa
Cytoplasmic: 1278-1306 aa

Phosphorylated by CK2 on Ser-1299; which allows membrane retention.