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PAX6 Matched Antibody Pair (844) (APMAB-844LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PAX6 polyclonal antibody, 100 ug
Detection Antibody
Anti-PAX6 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Alternative Names
Paired Box 6; Aniridia Type II Protein; Oculorhombin; AN2; Paired Box Gene 6 (Aniridia, Keratitis); Paired Box Homeotic Gene-6; Paired Box Protein Pax-6; Aniridia, Keratitis;
Entrez Gene ID
5080
UniProt ID
P26367
More Infomation

So, W. Y., Liao, Y., Liu, W. N., Rutter, G. A., & Han, W. (2023). Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy. EMBO Molecular Medicine, 15(12), e17928.

Li, Q., Liu, X., Xu, Y., Lu, Z., Jiang, S., & Yao, Y. (2023). Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes & Genetic Systems, 98(4), 161-169.

Zheng, Y., Yang, X., Wu, S., Yi, G., Huang, X., Feng, Z., ... & Xia, Z. (2022). Paired box gene 6 regulates heme oxygenase-1 expression and mitigates hydrogen peroxide-induced oxidative stress in lens epithelial cells. Current Eye Research, 47(11), 1516-1524.

So, W. Y., Liu, W. N., Teo, A. K. K., Rutter, G. A., & Han, W. (2021). Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Science translational medicine, 13(600), eabb1038.

Grocott, T., Lozano-Velasco, E., Mok, G. F., & Münsterberg, A. E. (2020). The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network. Development, 147(24), dev185827.

Cross, E., Duncan-Flavell, P. J., Howarth, R. J., Crooks, R. O., Thomas, N. S., & Bunyan, D. J. (2020). Screening of a large PAX6 cohort identified many novel variants and emphasises the importance of the paired and homeobox domains. European journal of medical genetics, 63(7), 103940.

Feng, Y., Li, M., Wang, S., Cong, W., Hu, G., Song, Y., ... & Zhang, Y. (2020). Paired box 6 inhibits cardiac fibroblast differentiation. Biochemical and Biophysical Research Communications, 528(3), 561-566.

Jin, M., Gao, D., Wang, R., Sik, A., & Liu, K. (2020). Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6. Oncology Reports, 44(2), 555-564.

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For research use only. Not intended for any clinical use.

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