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OPTN Matched Antibody Pair (832) (APMAB-832LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-OPTN polyclonal antibody, 100 ug
Detection Antibody
Anti-OPTN Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Alternative Names
Optineurin; Transcription Factor IIIA-Interacting Protein; Optic Neuropathy-Inducing Protein; Huntingtin-Interacting Protein 7; Huntingtin-Interacting Protein L; E3-14.7K-Interacting Protein; Huntingtin Yeast Partner L; TFIIIA-INTP; GLC1E; FIP-2; HIP-7; FIP2;
Entrez Gene ID
10133
UniProt ID
Q96CV9
More Infomation

Meyer, L. M., Koschade, S. E., Vischedyk, J. B., Thoelken, M., Gubas, A., Wegner, M., ... & Brandts, C. H. (2023). Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. Autophagy, 19(11), 2982-2996.

Patil, C. D., & Shukla, D. (2022). OPTN (optineurin)-mediated selective autophagy prevents neurodegeneration due to herpesvirus infection. Autophagy, 18(4), 944-945.

Qiu, Y., Wang, J., Li, H., Yang, B., Wang, J., He, Q., & Weng, Q. (2022). Emerging views of OPTN (optineurin) function in the autophagic process associated with disease. Autophagy, 18(1), 73-85.

Kakihana, T., Takahashi, M., Katsuragi, Y., Yamashita, S. I., Sango, J., Kanki, T., ... & Fujii, M. (2021). The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43. IScience, 24(7).

Ramachandran, G., Moharir, S. C., Raghunand, T. R., & Swarup, G. (2021). Optineurin modulates ER stress-induced signaling pathways and cell death. Biochemical and biophysical research communications, 534, 297-302.

Liu, Z. Z., Hong, C. G., Hu, W. B., Chen, M. L., Duan, R., Li, H. M., ... & Xie, H. (2021). Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. Autophagy, 17(10), 2766-2782.

Wang, J., Wang, J., Hong, W., Zhang, L., Song, L., Shi, Q., ... & Weng, Q. (2021). Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling. Nature Communications, 12(1), 6198.

Kurashige, T., Kuramochi, M., Ohsawa, R., Yamashita, Y., Shioi, G., Morino, H., ... & Kawakami, H. (2021). Optineurin defects cause TDP43-pathology with autophagic vacuolar formation. Neurobiology of Disease, 148, 105215.

Mizuno, N., Iwata, T., Ohsawa, R., Ouhara, K., Matsuda, S., Kajiya, M., ... & Kurihara, H. (2020). Optineurin regulates osteoblastogenesis through STAT1. Biochemical and Biophysical Research Communications, 525(4), 889-894.

Chen, K., Feng, L., Hu, W., Chen, J., Wang, X., Wang, L., & He, Y. (2019). Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy. The FASEB Journal, 33(3), 4571-4585.

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For research use only. Not intended for any clinical use.

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