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NRP1 Matched Antibody Pair (820) (APMAB-820LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-NRP1 monoclonal antibody, 100 ug
Detection Antibody
Anti-NRP1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Alternative Names
Neuropilin 1; Vascular Endothelial Cell Growth Factor 165 Receptor; VEGF165R; NRP; Transmembrane Receptor; CD304 Antigen;
Entrez Gene ID
8829
UniProt ID
O14786
More Infomation

Broz, M., Kolarič, A., Jukič, M., & Bren, U. (2022). Neuropilin (NRPs) related pathological conditions and their modulators. International journal of molecular sciences, 23(15), 8402.

Domingues, A., & Fantin, A. (2021). Neuropilin 1 regulation of vascular permeability signaling. Biomolecules, 11(5), 666.

Mayi, B. S., Leibowitz, J. A., Woods, A. T., Ammon, K. A., Liu, A. E., & Raja, A. (2021). The role of Neuropilin-1 in COVID-19. PLoS pathogens, 17(1), e1009153.

Gudowska-Sawczuk, M., & Mroczko, B. (2021). The role of neuropilin-1 (NRP-1) in SARS-CoV-2 infection. Journal of Clinical Medicine, 10(13), 2772.

Liu, S. D., Zhong, L. P., He, J., & Zhao, Y. X. (2021). Targeting neuropilin-1 interactions is a promising anti-tumor strategy. Chinese Medical Journal, 134(05), 508-517.

Jin, Q., Ren, Q., Chang, X., Yu, H., Jin, X., Lu, X., ... & Wang, G. (2021). Neuropilin-1 predicts poor prognosis and promotes tumor metastasis through epithelial-mesenchymal transition in gastric cancer. Journal of Cancer, 12(12), 3648.

Ding, Z., Du, W., Lei, Z., Zhang, Y., Zhu, J., Zeng, Y., ... & Huang, J. A. (2020). Neuropilin 1 modulates TGF‑β1‑induced epithelial‑mesenchymal transition in non‑small cell lung cancer. International journal of oncology, 56(2), 531-543.

Chuckran, C. A., Liu, C., Bruno, T. C., Workman, C. J., & Vignali, D. A. (2020). Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy. Journal for immunotherapy of cancer, 8(2).

Daly, J. L., Simonetti, B., Klein, K., Chen, K. E., Williamson, M. K., Antón-Plágaro, C., ... & Yamauchi, Y. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370(6518), 861-865.

Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., ... & Simons, M. (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity. Science, 370(6518), 856-860.

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For research use only. Not intended for any clinical use.

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