NPC2 Matched Antibody Pair (811) (APMAB-811LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-NPC2 monoclonal antibody, 100 ug

Detection Antibody

Anti-NPC2 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008]

Alternative Names

NPC Intracellular Cholesterol Transporter 2; Niemann-Pick Disease Type C2 Protein; Human Epididymis-Specific Protein 1; Epididymal Protein 1; HE1; Tissue-Specific Secretory Protein; Epididymal Secretory Protein E1; Niemann-Pick Disease, Type C2; EDDM1;

Entrez Gene ID

10577

UniProt ID

P61916

More Infomation

References

Qian, H., Wu, X., Du, X., Yao, X., Zhao, X., Lee, J., ... & Yan, N. (2020). Structural basis of low-pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. Cell, 182(1), 98-111.

Cologna, S. M., & Rosenhouse-Dantsker, A. (2019). Insights into the molecular mechanisms of cholesterol binding to the NPC1 and NPC2 proteins. Direct Mechanisms in Cholesterol Modulation of Protein Function, 139-160.

McCauliff, L. A., Langan, A., Li, R., Ilnytska, O., Bose, D., Waghalter, M., ... & Storch, J. (2019). Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid. Elife, 8, e50832.

Xu, Y., Zhang, Q., Tan, L., Xie, X., & Zhao, Y. (2019). The characteristics and biological significance of NPC2: Mutation and disease. Mutation Research/Reviews in Mutation Research, 782, 108284.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

NPC2 Matched Antibody Pair (812)

Antibody Pairs

NPC2 Matched Antibody Pair (812)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Second antibody and isotype control

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