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NDC80 Matched Antibody Pair (779) (APMAB-779LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-NDC80 monoclonal antibody, 100 ug
Detection Antibody
Anti-NDC80 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Alternative Names
NDC80, Kinetochore Complex Component; Retinoblastoma-Associated Protein HEC; Highly Expressed In Cancer Protein; Kinetochore-Associated Protein 2; Kinetochore Associated 2; Kinetochore Protein Hec1; HsHec1; KNTC2; HEC1; HEC;
Entrez Gene ID
10403
UniProt ID
O14777
More Infomation

Zahm, J. A., Jenni, S., & Harrison, S. C. (2023). Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface. Open Biology, 13(3), 220378.

Muir, K. W., Batters, C., Dendooven, T., Yang, J., Zhang, Z., Burt, A., & Barford, D. (2023). Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules. Science, 382(6675), 1184-1190.

Polley, S., Müschenborn, H., Terbeck, M., De Antoni, A., Vetter, I. R., Dogterom, M., ... & Huis in't Veld, P. J. (2023). Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding. The EMBO Journal, e112504.

Sarangapani, K. K., Koch, L. B., Nelson, C. R., Asbury, C. L., & Biggins, S. (2021). Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation. Journal of Cell Biology, 220(12), e202106130.

Dong, Q., Liu, X. L., Wang, X. H., Zhao, Y., Chen, Y. H., & Li, F. (2021). Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly. Proceedings of the National Academy of Sciences, 118(48), e2104459118.

Ustinov, N. B., Korshunova, A. V., & Gudimchuk, N. B. (2020). Protein complex NDC80: Properties, functions, and possible role in pathophysiology of cell division. Biochemistry (Moscow), 85, 448-462.

Wimbish, R. T., & DeLuca, J. G. (2020). Hec1/Ndc80 tail domain function at the kinetochore-microtubule interface. Frontiers in cell and developmental biology, 8, 43.

Wimbish, R. T., DeLuca, K. F., Mick, J. E., Himes, J., Jiménez-Sánchez, I., Jeyaprakash, A. A., & DeLuca, J. G. (2020). The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment. Molecular Biology of the Cell, 31(14), 1453-1473.

Brusini, L., D’Archivio, S., McDonald, J., & Wickstead, B. (2019). Ndc80/Nuf2-like protein KKIP1 connects a stable kinetoplastid outer kinetochore complex to the inner kinetochore and responds to metaphase tension. BioRxiv, 764829.

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For research use only. Not intended for any clinical use.

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