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NCF4 Matched Antibody Pair (777) (APMAB-777LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-NCF4 monoclonal antibody, 100 ug
Detection Antibody
Anti-NCF4 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Alternative Names
Neutrophil Cytosolic Factor 4; Neutrophil NADPH Oxidase Factor 4; SH3 And PX Domain-Containing Protein 4; Neutrophil Cytosolic Factor 4, 40kDa; P40-Phox; P40PHOX; SH3PXD4;
Entrez Gene ID
4689
UniProt ID
Q15080
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For research use only. Not intended for any clinical use.

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