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MUC1 Matched Antibody Pair (762) (APMAB-762LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-MUC1 monoclonal, IgG2b antibody, 100 ug
Detection Antibody
Anti-MUC1 Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Alternative Names
Mucin 1, Cell Surface Associated; Tumor-Associated Epithelial Membrane Antigen; Breast Carcinoma-Associated Antigen DF3; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Carcinoma-Associated Mucin; Mucin 1, Transmembrane; Krebs Von Den Lungen-6; Cancer Antigen 15-3; Episialin; CA 15-3; H23AG; MUC-1; KL-6; PEMT; EMA; PUM; PEM;
Entrez Gene ID
4582
UniProt ID
P15941
More Infomation

Iverson, E., Griswold, K., Song, D., Gagliardi, T. B., Hamidzadeh, K., Kesimer, M., ... & Scull, M. A. (2022). Membrane-tethered mucin 1 is stimulated by interferon and virus infection in multiple cell types and inhibits influenza a virus infection in human airway epithelium. Mbio, 13(4), e01055-22.

Supimon, K., Sangsuwannukul, T., Sujjitjoon, J., Phanthaphol, N., Chieochansin, T., Poungvarin, N., ... & Yenchitsomanus, P. T. (2021). Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma. Scientific reports, 11(1), 6276.

Ballester, B., Milara, J., & Cortijo, J. (2021). The role of mucin 1 in respiratory diseases. European Respiratory Review, 30(159).

Chen, W., Zhang, Z., Zhang, S., Zhu, P., Ko, J. K. S., & Yung, K. K. L. (2021). MUC1: structure, function, and clinic application in epithelial cancers. International Journal of Molecular Sciences, 22(12), 6567.

Kashyap, B., & Kullaa, A. M. (2020). Regulation of mucin 1 expression and its relationship with oral diseases. Archives of Oral Biology, 117, 104791.

Bose, M., & Mukherjee, P. (2020). Microbe–MUC1 crosstalk in cancer-associated infections. Trends in molecular medicine, 26(3), 324-336.

Gao, T., Cen, Q., & Lei, H. (2020). A review on development of MUC1-based cancer vaccine. Biomedicine & Pharmacotherapy, 132, 110888.

Dhar, P., & McAuley, J. (2019). The role of the cell surface mucin MUC1 as a barrier to infection and regulator of inflammation. Frontiers in cellular and infection microbiology, 9, 117.

Yousefi, M., Dehghani, S., Nosrati, R., Zare, H., Evazalipour, M., Mosafer, J., ... & Ramezani, M. (2019). Aptasensors as a new sensing technology developed for the detection of MUC1 mucin: A review. Biosensors and Bioelectronics, 130, 1-19.

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For research use only. Not intended for any clinical use.

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