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Mouse Anti-5-Methylcytosine Recombinant Antibody (V2-7700) (CBMAB-1872CQ)


See all 5-Methylcytosine antibodies
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Published Data
Mouse Anti-5-Methylcytosine Recombinant Antibody (CBLQ5-060) in IHC
Uveal melanoma. Overview of a globe with a uveal melanoma (astisk) close to the ciliary body (H&E stain). The immunohistochemical stains for H3Ac, H4 Ac, 5-MeC, 5-hMeC, UBC, and H2Aub shows a weaker nuclear staining reaction in the tumors compared to the adjacent choroid. The periphery of the tumor displays a more intense immunostaining than the center (illustrated for H3Ac, 5-MeC, 5-hMeC). ...View More
Herwig-Carl, M. C., Sharma, A., Höller, T., Holz, F. G., Schlitter, A. M., & Loeffler, K. U. (2019). Spatial intratumor heterogeneity in uveal melanoma: Tumor cell subtypes with a presumed invasive potential exhibit a particular epigenetic staining reaction. Experimental Eye Research, 182, 175-181.

Summary

Host Animal
Mouse
Clone
V2-7700
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, IF, IHC-F

Basic Information

Immunogen
5-Methylcytosine / 5-mC.
Host Species
Mouse
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
DB1:100-1:2,000
IHC1:100-1:1,000
IHC-F1:100-1:1,000
IHC-P1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-Methylcytosine
Introduction
5-Methylcytosine is a methylated form of the DNA base cytosine that may be involved in the regulation of gene transcription. When cytosine is methylated, the DNA maintains the same sequence, but the expression of methylated genes can be altered (the study of this is part of the field of epigenetics). 5-Methylcytosine is incorporated in the nucleoside 5-methylcytidine
Alternative Names
5-Methylcytosine; 554-01-8; Cytosine, 5-methyl-; 2(1H)-Pyrimidinone, 4-amino-5-methyl-; 5-Methylcytosine (VAN); 5 Methylcytosine; 5-mC
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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