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MMP3 Matched Antibody Pair (741) (APMAB-741LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-MMP3 polyclonal antibody, 100 ug
Detection Antibody
Anti-MMP3 Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Alternative Names
Matrix Metallopeptidase 3; Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase); EC 3.4.24.17; Transin-1; STMY1; MMP-3; SL-1; Matrix Metalloproteinase-3;
Entrez Gene ID
4314
UniProt ID
P08254
More Infomation

Jehan, F., Zarka, M., de la Houssaye, G., Veziers, J., Ostertag, A., Cohen‐Solal, M., & Geoffroy, V. (2022). New insights into the role of matrix metalloproteinase 3 (MMP3) in bone. FASEB BioAdvances, 4(8), 524.

Kageyama, Y., Nakamura, M., Igari, Y., Yamaguchi, S., Oguchi, A., Murakawa, Y., ... & Sasano, Y. (2022). Expression of matrix metalloproteinase‐3 and‐10 is up‐regulated in the periodontal tissues of aged mice. Journal of Periodontal Research, 57(4), 733-741.

Wan, J., Zhang, G., Li, X., Qiu, X., Ouyang, J., Dai, J., & Min, S. (2021). Matrix metalloproteinase 3: a promoting and destabilizing factor in the pathogenesis of disease and cell differentiation. Frontiers in Physiology, 12, 663978.

Shi, S., Su, M., Shen, G., Hu, Y., Yi, F., Zeng, Z., ... & Xie, X. (2021). Matrix metalloproteinase 3 as a valuable marker for patients with COVID‐19. Journal of medical virology, 93(1), 528-532.

Suhaimi, S. A., Chan, S. C., & Rosli, R. (2020). Matrix metallopeptidase 3 polymorphisms: Emerging genetic markers in human breast cancer metastasis. Journal of breast cancer, 23(1), 1-9.

Balkhi, S., Mashayekhi, F., Salehzadeh, A., & Saedi, H. S. (2020). Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and-3 serum concentration and associates with breast cancer. Molecular Biology Reports, 47(12), 9637-9644.

Manka, S. W., Bihan, D., & Farndale, R. W. (2019). Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling. Scientific reports, 9(1), 18785.

Lee, J. M., Kronbichler, A., Park, S. J., Kim, S. H., Han, K. H., Kang, H. G., ... & Shin, J. I. (2019). Association between serum matrix metalloproteinase-(MMP-) 3 levels and systemic lupus erythematosus: a meta-analysis. Disease markers, 2019.

Lech, A. M., Wiera, G., & Mozrzymas, J. W. (2019). Matrix metalloproteinase-3 in brain physiology and neurodegeneration. Advances in Clinical and Experimental Medicine, 28(12), 1717-1722.

Mirastschijski, U., Lupše, B., Maedler, K., Sarma, B., Radtke, A., Belge, G., ... & Ågren, M. S. (2019). Matrix metalloproteinase-3 is key effector of TNF-α-induced collagen degradation in skin. International journal of molecular sciences, 20(20), 5234.

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For research use only. Not intended for any clinical use.

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