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KIT Matched Antibody Pair (668) (APMAB-668LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-KIT monoclonal antibody, 100 ug
Detection Antibody
Anti-KIT Biotinylated mouse monoclonal, IgG2a antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
KIT Proto-Oncogene Receptor Tyrosine Kinase; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Tyrosine-Protein Kinase Kit; Piebald Trait Protein; Proto-Oncogene C-Kit; EC 2.7.10.1; P145 C-Kit; SCFR; PBT; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein;
Entrez Gene ID
3815
UniProt ID
P10721
More Infomation

Sheikh, E., Tran, T., Vranic, S., Levy, A., & Bonfil, R. D. (2022). Role and significance of c-KIT receptor tyrosine kinase in cancer: A review. Bosnian Journal of Basic Medical Sciences, 22(5), 683.

Naumann, N., Lübke, J., Shomali, W., Reiter, L., Horny, H. P., Jawhar, M., ... & Schwaab, J. (2021). Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto‐oncogene, receptor tyrosine kinase (KIT) D816V mutations. British journal of haematology, 194(2), 344-354.

K. Bhanumathy, K., Balagopal, A., Vizeacoumar, F. S., Vizeacoumar, F. J., Freywald, A., & Giambra, V. (2021). Protein tyrosine kinases: their roles and their targeting in leukemia. Cancers, 13(2), 184.

Esteban-Villarrubia, J., Soto-Castillo, J. J., Pozas, J., San Román-Gil, M., Orejana-Martín, I., Torres-Jiménez, J., ... & Molina-Cerrillo, J. (2020). Tyrosine kinase receptors in oncology. International journal of molecular sciences, 21(22), 8529.

Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., ... & Manuel Afonso Moreira, J. (2019). Metallopeptidase inhibitor 1 (TIMP‐1) promotes receptor tyrosine kinase c‐Kit signaling in colorectal cancer. Molecular Oncology, 13(12), 2646-2662.

Roskoski Jr, R. (2018). The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders. Pharmacological research, 133, 35-52.

Wang, H., Boussouar, A., Mazelin, L., Tauszig-Delamasure, S., Sun, Y., Goldschneider, D., ... & Mehlen, P. (2018). The proto-oncogene c-Kit inhibits tumor growth by behaving as a dependence receptor. Molecular cell, 72(3), 413-425.

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For research use only. Not intended for any clinical use.

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