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IRF3 Matched Antibody Pair (647) (APMAB-647LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IRF3 polyclonal antibody, 100 ug
Detection Antibody
Anti-IRF3 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Alternative Names
Interferon Regulatory Factor 3
Entrez Gene ID
3661
UniProt ID
Q14653
More Infomation

Su, J., Guan, B., Chen, K., Feng, Z., Guo, K., Wang, X., ... & Chen, Q. (2023). Fucoxanthin attenuates inflammation via interferon regulatory factor 3 (IRF3) to improve sepsis. Journal of Agricultural and Food Chemistry, 71(33), 12497-12510.

Freitas, R. S., Crum, T. F., & Parvatiyar, K. (2022). SARS-CoV-2 spike antagonizes innate antiviral immunity by targeting interferon regulatory factor 3. Frontiers in Cellular and Infection Microbiology, 11, 1350.

Rashid, F., Suleman, M., Shah, A., Dzakah, E. E., Wang, H., Chen, S., & Tang, S. (2021). Mutations in SARS-CoV-2 ORF8 altered the bonding network with interferon regulatory factor 3 to evade host immune system. Frontiers in Microbiology, 12, 703145.

Glanz, A., Chakravarty, S., Varghese, M., Kottapalli, A., Fan, S., Chakravarti, R., & Chattopadhyay, S. (2021). Transcriptional and non-transcriptional activation, posttranslational modifications, and antiviral functions of interferon regulatory factor 3 and viral antagonism by the SARS-coronavirus. Viruses, 13(4), 575.

Tang, P., Virtue, S., Goie, J. Y. G., Png, C. W., Guo, J., Li, Y., ... & Zhang, Y. (2021). Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell Death & Differentiation, 28(11), 3022-3035.

Petro, T. M. (2020). IFN regulatory factor 3 in health and disease. The Journal of Immunology, 205(8), 1981-1989.

Guinn, Z. P., & Petro, T. M. (2019). Interferon regulatory factor 3 plays a role in macrophage responses to interferon-γ. Immunobiology, 224(4), 565-574.

Sanz‐Garcia, C., McMullen, M. R., Chattopadhyay, S., Roychowdhury, S., Sen, G., & Nagy, L. E. (2019). Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High‐Fat Diet‐Induced Liver Injury. Hepatology Communications, 3(12), 1626-1641.

Wong, H. H., Fung, T. S., Fang, S., Huang, M., Le, M. T., & Liu, D. X. (2018). Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3. Virology, 515, 165-175.

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For research use only. Not intended for any clinical use.

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