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IL6R Matched Antibody Pair (638) (APMAB-638LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-IL6R monoclonal antibody, 100 ug
Detection Antibody
Anti-IL6R Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
Alternative Names
Interleukin 6 Receptor
Entrez Gene ID
3570
UniProt ID
P08887
More Infomation

Hamilton, F. W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., ... & Timpson, N. J. (2023). Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study. PLoS Medicine, 20(1), e1004174.

Maiti, S., Banerjee, A., Nazmeen, A., Kanwar, M., & Das, S. (2022). Active-site molecular docking of nigellidine with nucleocapsid–NSP2–MPro of COVID-19 and to human IL1R–IL6R and strong antioxidant role of Nigella sativa in experimental rats. Journal of Drug Targeting, 30(5), 511-521.

Teoh, P. J., Chung, T. H., Chng, P. Y., Toh, S. H., & Chng, W. J. (2020). IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification. haematologica, 105(5), 1391.

Strafella, C., Caputo, V., Termine, A., Barati, S., Caltagirone, C., Giardina, E., & Cascella, R. (2020). Investigation of genetic variations of IL6 and IL6R as potential prognostic and pharmacogenetics biomarkers: implications for COVID-19 and neuroinflammatory disorders. Life, 10(12), 351.

Nouri, B., Nair, N., & Barton, A. (2020). Predicting treatment response to IL6R blockers in rheumatoid arthritis. Rheumatology, 59(12), 3603-3610.

Buonaguro, F. M., Puzanov, I., & Ascierto, P. A. (2020). Anti-IL6R role in treatment of COVID-19-related ARDS. Journal of translational medicine, 18, 1-2.

Jia, C., Wang, G., Wang, T., Fu, B., Zhang, Y., Huang, L., ... & Liu, W. (2020). Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma. International journal of biological sciences, 16(14), 2542.

Deng, N., Li, L., Gao, J., Zhou, J., Wang, Y., Wang, C., & Liu, Y. (2018). Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. Biochemical and biophysical research communications, 495(1), 189-196.

Tamura, Y., Phan, C., Tu, L., Le Hiress, M., Thuillet, R., Jutant, E. M., ... & Guignabert, C. (2018). Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension. The Journal of clinical investigation, 128(5), 1956-1970.

Zhang, B., Yu, L., Han, N., Hu, Z., Wang, S., Ding, L., & Jiang, J. (2018). LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway. Biomedicine & Pharmacotherapy, 107, 270-282.

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For research use only. Not intended for any clinical use.

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