HMGB1 Matched Antibody Pair (552) (APMAB-552LY)

See all HMGB1 antibodies

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-HMGB1 monoclonal antibody, 100 ug

Detection Antibody

Anti-HMGB1 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Alternative Names

High Mobility Group Box 1; High-Mobility Group (Nonhistone Chromosomal) Protein 1; Sulfoglucuronyl Carbohydrate Binding Protein; High Mobility Group Protein 1; Amphoterin; HMG-1;

Entrez Gene ID

3146

UniProt ID

P09429

More Infomation

References

Chen, R., Kang, R., & Tang, D. (2022). The mechanism of HMGB1 secretion and release. Experimental & molecular medicine, 54(2), 91-102.

Xue, J., Suarez, J. S., Minaai, M., Li, S., Gaudino, G., Pass, H. I., ... & Yang, H. (2021). HMGB1 as a therapeutic target in disease. Journal of cellular physiology, 236(5), 3406-3419.

Volchuk, A., Ye, A., Chi, L., Steinberg, B. E., & Goldenberg, N. M. (2020). Indirect regulation of HMGB1 release by gasdermin D. Nature communications, 11(1), 4561.

Yang, H., Wang, H., & Andersson, U. (2020). Targeting inflammation driven by HMGB1. Frontiers in immunology, 11, 484.

Wang, S., & Zhang, Y. (2020). HMGB1 in inflammation and cancer. Journal of hematology & oncology, 13(1), 1-4.

Chen, R., Huang, Y., Quan, J., Liu, J., Wang, H., Billiar, T. R., ... & Tang, D. (2020). HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon, 6(12).

Pellegrini, L., Foglio, E., Pontemezzo, E., Germani, A., Russo, M. A., & Limana, F. (2019). HMGB1 and repair: focus on the heart. Pharmacology & therapeutics, 196, 160-182.

Wen, Q., Liu, J., Kang, R., Zhou, B., & Tang, D. (2019). The release and activity of HMGB1 in ferroptosis. Biochemical and biophysical research communications, 510(2), 278-283.

Andersson, U., Yang, H., & Harris, H. (2018). Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert opinion on therapeutic targets, 22(3), 263-277.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

HMGB1 Matched Antibody Pair (550)

HMGB1 Matched Antibody Pair (551)

HMGB1 Matched Antibody Pair (553)

HMGB1 Matched Antibody Pair (554)

Antibody Pairs

HMGB1 Matched Antibody Pair (550)

HMGB1 Matched Antibody Pair (551)

HMGB1 Matched Antibody Pair (553)

HMGB1 Matched Antibody Pair (554)

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HMGB1 Matched Antibody Pair (550)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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