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HLA-DPA1 Matched Antibody Pair (546) (APMAB-546LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HLA-DPA1 polyclonal antibody, 100 ug
Detection Antibody
Anti-HLA-DPA1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Alternative Names
Major Histocompatibility Complex, Class II, DP Alpha 1; MHC Class II DP3-Alpha; HLA-SB Alpha Chain; HLA-DP1A; DP(W3); DP(W4); HLASB;
Entrez Gene ID
3113
UniProt ID
P20036
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For research use only. Not intended for any clinical use.

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