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HLA-A Matched Antibody Pair (544) (APMAB-544LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HLA-A polyclonal antibody, 100 ug
Detection Antibody
Anti-HLA-A Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
Alternative Names
Major Histocompatibility Complex, Class I, A; HLA Class I Histocompatibility Antigen, A-1 Alpha Chain; HLAA; HLA Class I Histocompatibility Antigen, A-10 Alpha Chain; HLA Class I Histocompatibility Antigen, A-28 Alpha Chain; HLA Class I Histocompatibility Antigen, A-9 Alpha Chain; MHC Class I Antigen HLA-A Heavy Chain; Leukocyte Antigen Class I-A; MHC Class I Antigen A*11; MHC Class I Antigen A*23; MHC Class I Antigen A*24; MHC Class I Antigen A*25; MHC Class I Antigen A*26; MHC Class I Antigen A*29; MHC Class I Antigen A*30; MHC Class I Antigen A*31; MHC Class I Antigen A*32; MHC Class I Antigen A*33; MHC Class I Antigen A*34; MHC Class I Antigen A*36; MHC Class I Antigen A*43;
Entrez Gene ID
3105
UniProt ID
P01891
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For research use only. Not intended for any clinical use.

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