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HDAC3 Matched Antibody Pair (531) (APMAB-531LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-HDAC3 monoclonal antibody, 100 ug
Detection Antibody
Anti-HDAC3 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Alternative Names
Histone Deacetylase 3; EC 3.5.1.98; RPD3-2; SMAP45; HD3; RPD3;
Entrez Gene ID
8841
UniProt ID
O15379
More Infomation

He, R., Liu, B., Geng, B., Li, N., & Geng, Q. (2023). The role of HDAC3 and its inhibitors in regulation of oxidative stress and chronic diseases. Cell Death Discovery, 9(1), 131.

Eshleman, E. M., Shao, T. Y., Woo, V., Rice, T., Engleman, L., Didriksen, B. J., ... & Alenghat, T. (2023). Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. The Journal of Clinical Investigation, 133(4).

Li, W., Kou, J., Qin, J., Li, L., Zhang, Z., Pan, Y., ... & Du, W. (2021). NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex. Nature Metabolism, 3(1), 75-89.

Wu, S. E., Hashimoto-Hill, S., Woo, V., Eshleman, E. M., Whitt, J., Engleman, L., ... & Alenghat, T. (2020). Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature, 586(7827), 108-112.

Nguyen, H. C., Adlanmerini, M., Hauck, A. K., & Lazar, M. A. (2020). Dichotomous engagement of HDAC3 activity governs inflammatory responses. Nature, 584(7820), 286-290.

Kim, T. H., Yoo, J. Y., Choi, K. C., Shin, J. H., Leach, R. E., Fazleabas, A. T., ... & Jeong, J. W. (2019). Loss of HDAC3 results in nonreceptive endometrium and female infertility. Science translational medicine, 11(474), eaaf7533.

Ji, H., Zhou, Y., Zhuang, X., Zhu, Y., Wu, Z., Lu, Y., ... & Bu, H. (2019). HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition. Cancer research, 79(14), 3676-3688.

Janczura, K. J., Volmar, C. H., Sartor, G. C., Rao, S. J., Ricciardi, N. R., Lambert, G., ... & Wahlestedt, C. (2018). Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model. Proceedings of the National Academy of Sciences, 115(47), E11148-E11157.

Adhikari, N., Amin, S. A., Trivedi, P., Jha, T., & Ghosh, B. (2018). HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches. European journal of medicinal chemistry, 157, 1127-1142.

Whitt, J., Woo, V., Lee, P., Moncivaiz, J., Haberman, Y., Denson, L., ... & Alenghat, T. (2018). Disruption of epithelial HDAC3 in intestine prevents diet-induced obesity in mice. Gastroenterology, 155(2), 501-513.

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For research use only. Not intended for any clinical use.

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