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GIT2 Matched Antibody Pair (483) (APMAB-483LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-GIT2 monoclonal antibody, 100 ug
Detection Antibody
Anti-GIT2 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Alternative Names
GIT ArfGAP 2; G Protein-Coupled Receptor Kinase Interacting ArfGAP 2; Cool-Interacting Tyrosine-Phosphorylated Protein 2; G Protein-Coupled Receptor Kinase-Interactor 2; GRK-Interacting Protein 2; Paxillin Kinase Linker; ARF GAP GIT2; CAT-2;
Entrez Gene ID
9815
UniProt ID
Q14161
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For research use only. Not intended for any clinical use.

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