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FKBP5 Matched Antibody Pair (447) (APMAB-447LY)


See all FKBP5 antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FKBP5 polyclonal antibody, 100 ug
Detection Antibody
Anti-FKBP5 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Alternative Names
FK506 Binding Protein 5; 54 KDa Progesterone Receptor-Associated Immunophilin; 51 KDa FK506-Binding Protein; Androgen-Regulated Protein 6; HSP90-Binding Immunophilin; FK506-Binding Protein 5; PPIase FKBP5; 51 KDa FKBP; FF1 Antigen; EC 5.2.1.8; Rotamase; FKBP-51;
Entrez Gene ID
2289
UniProt ID
Q13451
More Infomation

Kageyama, K., Iwasaki, Y., Watanuki, Y., Niioka, K., & Daimon, M. (2021). Differential effects of Fkbp4 and Fkbp5 on regulation of the proopiomelanocortin gene in murine AtT-20 corticotroph cells. International Journal of Molecular Sciences, 22(11), 5724.

Bierer, L. M., Bader, H. N., Daskalakis, N. P., Lehrner, A., Provençal, N., Wiechmann, T., ... & Yehuda, R. (2020). Intergenerational effects of maternal holocaust exposure on FKBP5 methylation. American Journal of Psychiatry, 177(8), 744-753.

Zannas, A. S., Jia, M., Hafner, K., Baumert, J., Wiechmann, T., Pape, J. C., ... & Binder, E. B. (2019). Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk. Proceedings of the National Academy of Sciences, 116(23), 11370-11379.

Klinger-König, J., Hertel, J., Van der Auwera, S., Frenzel, S., Pfeiffer, L., Waldenberger, M., ... & Grabe, H. J. (2019). Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression. Neuropsychopharmacology, 44(5), 930-938.

Hawn, S. E., Sheerin, C. M., Lind, M. J., Hicks, T. A., Marraccini, M. E., Bountress, K., ... & Amstadter, A. B. (2019). GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis. Journal of Affective Disorders, 243, 455-462.

Roberts, S., Keers, R., Breen, G., Coleman, J. R., Jöhren, P., Kepa, A., ... & Wong, C. C. (2019). DNA methylation of FKBP5 and response to exposure‐based psychological therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(2), 150-158.

Ising, M., Maccarrone, G., Brückl, T., Scheuer, S., Hennings, J., Holsboer, F., ... & Lucae, S. (2019). FKBP5 gene expression predicts antidepressant treatment outcome in depression. International journal of molecular sciences, 20(3), 485.

Wang, Q., Shelton, R. C., & Dwivedi, Y. (2018). Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis. Journal of affective disorders, 225, 422-428.

Matosin, N., Halldorsdottir, T., & Binder, E. B. (2018). Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model. Biological psychiatry, 83(10), 821-830.

Tozzi, L., Farrell, C., Booij, L., Doolin, K., Nemoda, Z., Szyf, M., ... & Frodl, T. (2018). Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression. Neuropsychopharmacology, 43(5), 1138-1145.

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For research use only. Not intended for any clinical use.

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