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FGF12 Matched Antibody Pair (430) (APMAB-430LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-FGF12 polyclonal antibody, 100 ug
Detection Antibody
Anti-FGF12 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Alternative Names
Fibroblast Growth Factor 12; Fibroblast Growth Factor Homologous Factor 1; Myocyte-Activating Factor; Fibroblast Growth Factor FGF-12b; Fibroblast Growth Factor 12B; FGF12B;
Entrez Gene ID
2257
UniProt ID
P61328
More Infomation

Woo, J., Suh, W., & Sung, J. H. (2022). Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12). International Journal of Molecular Sciences, 23(16), 9467.

Liu, A., Zhang, Y., Xun, S., Zhou, G., Lin, L., & Mei, Y. (2022). Fibroblast growth factor 12 attenuated cardiac remodeling via suppressing oxidative stress. Peptides, 153, 170786.

Gao, X., Liao, Z., Su, R., Zheng, D., Huang, G., Huang, Z., & Cheng, X. (2022). Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer. BioMed Research International, 2022.

Zhou, M., Chen, J., Meng, K., Zhang, Y., Zhang, M., Lu, P., ... & Tian, H. (2021). Production of bioactive recombinant human fibroblast growth factor 12 using a new transient expression vector in E. coli and its neuroprotective effects. Applied Microbiology and Biotechnology, 105(13), 5419-5431.

Yeo, Y., Yi, E. S., Kim, J. M., Jo, E. K., Seo, S., Kim, R. I., ... & Suh, W. (2020). FGF12 (fibroblast growth factor 12) inhibits vascular smooth muscle cell remodeling in pulmonary arterial hypertension. Hypertension, 76(6), 1778-1786.

Wu, J., Huang, H., Huang, Q., Qiu, R., Huang, M., & Meng, D. (2020). A functional variant rs1464938 in the promoter of fibroblast growth factor 12 is associated with an increased risk of bladder transitional cell carcinoma. Cytokine, 136, 155294.

Hanada, Y., Nakamura, Y., Ozono, Y., Ishida, Y., Takimoto, Y., Taniguchi, M., ... & Shimada, S. (2018). Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function. Scientific reports, 8(1), 1-10.

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For research use only. Not intended for any clinical use.

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