F2 Matched Antibody Pair (396) (APMAB-396LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-F2 monoclonal, IgG antibody, 100 ug

Detection Antibody

Anti-F2 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Alternative Names

Coagulation Factor II, Thrombin; Prepro-Coagulation Factor II; EC 3.4.21.5; Coagulation Factor II (Thrombin); Coagulation Factor II; Prothrombin B-Chain; Serine Protease;

Entrez Gene ID

2147

UniProt ID

P00734

More Infomation

References

Natasya, N., Tyniana, T. E. R. A., Savero, S., Swastika, N., & PARIKESIT, A. A. (2021). In silico computation of coagulation factor II: a potential water treatment agent against gram negative bacteria. Notulae Scientia Biologicae, 13(3), 11021-11021.

Tang, Y., Zhang, L., Xie, W., Jin, J., Luo, Y., Deng, M., ... & Fan, L. L. (2020). A Novel Heterozygous Variant in F2 Gene in a Chinese Patient With Coronary Thrombosis and Acute Myocardial Infarction Leads to Antithrombin Resistance. Frontiers in Genetics, 11, 184.

Takenouchi, T., Shimada, H., Uehara, T., Kanai, Y., Takahashi, T., & Kosaki, K. (2019). A paradoxical thrombogenic mutation in factor II at the target site of arthropod bleeding toxin. European Journal of Medical Genetics, 62(2), 93-95.

Zimowski, K. L., & Meeks, S. L. (2019). Factor II, Factor V, and Factor X Deficiencies. In Transfusion Medicine and Hemostasis (pp. 699-702). Elsevier.

Chinnaraj, M., Planer, W., & Pozzi, N. (2018). Structure of coagulation factor II: molecular mechanism of thrombin generation and development of next-generation anticoagulants. Frontiers in Medicine, 5, 281.

Farshi, Y., Dorgalaleh, A., & Tabibian, S. (2018). Congenital Factor II Deficiency. In Congenital Bleeding Disorders (pp. 183-199). Springer, Cham.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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