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EDN1 Matched Antibody Pair (363) (APMAB-363LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-EDN1 monoclonal, IgG2a antibody, 100 ug
Detection Antibody
Anti-EDN1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Alternative Names
Endothelin 1; Preproendothelin-1; PPET1; Endothelin-1; ARCND3; HDLCQ7; ET1; QME;
Entrez Gene ID
1906
UniProt ID
P05305
More Infomation

Lazurova, Z., Habalova, V., & Mitro, P. (2022). Association of Polymorphisms in Endothelin-1 and Endothelin Receptor A Genes With Vasovagal Syncope. Physiological Research, 71(1), 93.

Hwang, C. Y., Yu, S. J., Won, J. K., Park, S. M., Noh, H., Lee, S., ... & Cho, K. H. (2022). Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor. Cancer Gene Therapy, 29(6), 845-858.

Hwang, I., Lee, E. J., Park, H., Moon, D., Park, J. N., Kim, K. C., ... & Kim, H. S. (2021). Endothelin-1 enhances the regenerative capability of human bone marrow-derived mesenchymal stem cells in a sciatic nerve injury mouse model. Biomaterials, 275, 120980.

Torres Crigna, A., Link, B., Samec, M., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2021). Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine. EPMA Journal, 12(3), 265-305.

Douma, L. G., Solocinski, K., Masten, S. H., Barral, D. H., Barilovits, S. J., Jeffers, L. A., ... & Gumz, M. L. (2020). EDN1-AS, a novel long non-coding RNA regulating endothelin-1 in human proximal tubule cells. Frontiers in Physiology, 11, 209.

Zhang, L., Chen, L., Gao, C., Chen, E., Lightle, A. R., Foulke, L., ... & Zhang, W. (2020). Loss of histone H3 K79 methyltransferase Dot1l facilitates kidney fibrosis by upregulating endothelin 1 through histone deacetylase 2. Journal of the American Society of Nephrology, 31(2), 337-349.

Alcendor, D. J. (2020). Dysregulation of Endothelin-1: Implications for Health Disparities in Alzheimer’s Disease. Journal of Personalized Medicine, 10(4), 199.

Smiianova, Y. O., Pristupa, L. N., Harbuzova, V. Y., & Harbuzova, Y. A. (2019). The association of LYS198ASN-polymorphism of endothelin-1 gene (EDN1) with development of arterial hypertension in ukrainian population. Wiadomosci Lekarskie (Warsaw, Poland: 1960), 72(4), 568-574.

Liang, L. L., Chen, L., Zhou, M. Y., Cai, M. Y., Cheng, J., Chen, Y., ... & Xiong, X. D. (2018). Genetic susceptibility of five tagSNPs in the endothelin-1 (EDN1) gene to coronary artery disease in a Chinese Han population. Bioscience reports, 38(5).

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For research use only. Not intended for any clinical use.

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