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DUSP12 Matched Antibody Pair (353) (APMAB-353LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-DUSP12 polyclonal antibody, 100 ug
Detection Antibody
Anti-DUSP12 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]
Alternative Names
Dual Specificity Phosphatase 12; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Tyrosine Phosphatase YVH1; YVH1 Protein-Tyrosine Phosphatase (S. Cerevisiae) Ortholog; YVH1 Protein-Tyrosine Phosphatase Ortholog; Dual Specificity Protein Phosphatase 12;
Entrez Gene ID
11266
UniProt ID
Q9UNI6
More Infomation

Boldorini, R., Clemente, N., Alchera, E., & Carini, R. (2021). DUSP12 acts as a novel endogenous protective signal against hepatic ischemia–reperfusion damage by inhibiting ASK1 pathway. Clinical Science, 135(1), 161-166.

Ju, G., Zhou, T., Zhang, R., Pan, X., Xue, B., & Miao, S. (2021). DUSP12 regulates the tumorigenesis and prognosis of hepatocellular carcinoma. PeerJ, 9, e11929.

Qiu, T., Wang, T., Zhou, J., Chen, Z., Zou, J., Zhang, L., & Ma, X. (2020). DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo. Clinical Science, 134(17), 2279-2294.

Huang, Z., Wu, L. M., Zhang, J. L., Sabri, A., Wang, S. J., Qin, G. J., ... & Zhang, Y. Z. (2019). Dual specificity phosphatase 12 regulates hepatic lipid metabolism through inhibition of the lipogenesis and apoptosis signal–regulating kinase 1 pathways. Hepatology, 70(4), 1099-1118.

Monteiro, L. F., & Forti, F. L. (2019). Network analysis of DUSP12 partners in the nucleus under genotoxic stress. Journal of proteomics, 197, 42-52.

Cho, S. S. L., Han, J., James, S. J., Png, C. W., Weerasooriya, M., Alonso, S., & Zhang, Y. (2017). Dual-specificity phosphatase 12 targets p38 MAP kinase to regulate macrophage response to intracellular bacterial infection. Frontiers in immunology, 8, 1259.

Li, W. M., Zhao, Y. F., Zhu, G. F., Peng, W. H., Zhu, M. Y., Yu, X. J., ... & Xu, Y. W. (2017). Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Clinical Science, 131(2), 141-154.

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For research use only. Not intended for any clinical use.

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