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CASQ2 Matched Antibody Pair (184) (APMAB-184LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CASQ2 polyclonal antibody, 100 ug
Detection Antibody
Anti-CASQ2 Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]
Alternative Names
Calsequestrin 2; Calsequestrin, Cardiac Muscle Isoform; Calsequestrin 2 (Cardiac Muscle); Calsequestrin 2, Fast-Twitch, Cardiac Muscle; Calsequestrin-2; PDIB2;
Entrez Gene ID
845
UniProt ID
O14958
More Infomation

Kim, J. H., Lee, E. S., Yun, J., Ryu, H. S., Kim, H. K., Ju, Y. W., ... & Moon, H. G. (2021). Calsequestrin 2 overexpression in breast cancer increases tumorigenesis and metastasis by modulating the tumor microenvironment. Molecular Oncology.

Valle, G., Arad, M., & Volpe, P. (2020). Molecular adaptation to calsequestrin 2 (CASQ2) point mutations leading to catecholaminergic polymorphic ventricular tachycardia (CPVT): comparative analysis of R33Q and D307H mutants. Journal of muscle research and cell motility, 41(2), 251-258.

Ross, S., Holliday, M., Lim, S., & Semsarian, C. (2019). Characterization of the first induced pluripotent stem cell line generated from a patient with autosomal dominant catecholaminergic polymorphic ventricular tachycardia due to a heterozygous mutation in cardiac calsequestrin-2. Stem cell research, 37, 101450.

Kim, J. H., sil Hong, B., Heo, W., Han, J. M., Han, W., Noh, D. Y., & Moon, H. G. (2018). Calsequestrin 2 regulates proliferation, migration, and invasion in triple-negative breast cancer cells.

Rebrova, T. Y., Muslimova, E. F., Kondratieva, D. S., Budnikova, O. V., Ahmedov, S. D., Afanasiev, S. A., & Popov, S. V. (2018). The Role of Ca 2+-ATPase 2a (ATP2A2), Ryanodine Receptors (RYR2), and Calsequestrin (CASQ2) Gene Polymorphisms in the Development of Heart Failure. Russian Journal of Genetics, 54(6), 604-608.

Josephs, K., Patel, K., Janson, C. M., Montagna, C., & McDonald, T. V. (2017). Compound heterozygous CASQ 2 mutations and long‐term course of catecholaminergic polymorphic ventricular tachycardia. Molecular genetics & genomic medicine, 5(6), 788-794.

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For research use only. Not intended for any clinical use.

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