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Mouse Anti-ZWILCH Recombinant Antibody (1C9) (CBMAB-Z0793-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C9
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
ZWILCH (AA1-477) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
Zwilch, kinetochore associated, homolog (Drosophila)
Introduction
Zwilch Kinetochore Protein
Entrez Gene ID
55055
UniProt ID
Q9H900
Alternative Names
KNTC1AP; hZwilch
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process protein localization to kinetochore Source:UniProtKB1 Publication
Cellular Location
Chromosome, centromere, kinetochore
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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