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Rat Anti-ZP1 Recombinant Antibody (CBWJZ-277) (CBMAB-Z0714-WJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJZ-277
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
zona pellucida glycoprotein 1
Introduction
ZP1 (Zona Pellucida Glycoprotein 1) is a Protein Coding gene. Diseases associated with ZP1 include Oocyte Maturation Defect 1 and Female Infertility Due To Zona Pellucida Defect. Among its related pathways are Reproduction. An important paralog of this gene is ZP4.
Entrez Gene ID
22786
UniProt ID
Q62005
Alternative Names
OOMD; OOMD1; HEL163
Function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Biological Process
Biological Process binding of sperm to zona pellucida Source:GO_Central1 Publication
Biological Process prevention of polyspermy Source:GO_Central1 Publication
Cellular Location
Processed zona pellucida sperm-binding protein 1
Zona pellucida
Cell membrane
Involvement in disease
Oocyte maturation defect 1 (OOMD1):
An infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa.
Topology
Extracellular: 26-601
Helical: 602-622
Cytoplasmic: 623-638
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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