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Mouse Anti-ZNF683 Recombinant Antibody (1E4) (CBMAB-0732-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E4
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Full length
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
zinc finger protein 683
Introduction
ZNF683 may be involved in transcriptional regulation.
Entrez Gene ID
257101
UniProt ID
Q8IZ20
Alternative Names
MGC33414
Function
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Also plays a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.
Isoform 1
Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T-cells.
Isoform 2
Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8+ T cells.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cellular response to ionomycin Source:UniProtKB
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB
Biological Process negative regulation of type II interferon production Source:UniProtKB
Biological Process positive regulation of gene expression Source:UniProtKB
Biological Process regulation of extrathymic T cell differentiation Source:UniProtKB
Biological Process regulation of gene expression Source:UniProtKB
Biological Process regulation of natural killer cell differentiation Source:UniProtKB
Biological Process regulation of natural killer cell differentiation involved in immune response Source:UniProtKB
Biological Process regulation of NK T cell differentiation Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process T cell receptor signaling pathway Source:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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