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Mouse Anti-YWHAB Antibody (2BA3) (CBMAB-1816CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2BA3
Antibody Isotype
IgG2c
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
YWHAB
Introduction
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Diseases associated with YWHAB include Gerstmann-Straussler Disease. Among its related pathways are DNA Damage and RET signaling.
Entrez Gene ID
7529
UniProt ID
P31946
Alternative Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; alpha polypeptide; Protein 1054; Protein kinase C inhibitor Protein 1; KCIP-1; 14-3-3 alpha; 14-3-3 protein beta/alpha; GW128; HS1; YWHAA; brain protein 14-3-3; beta isoforms; protein kinase C inhibitor protein 1;
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Biological Process
Biological Process cytoplasmic sequestering of protein Source:BHF-UCL1 Publication
Biological Process negative regulation of G protein-coupled receptor signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of protein dephosphorylation Source:BHF-UCL1 Publication
Biological Process positive regulation of catalytic activity Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Vacuole membrane
(Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.
PTM
The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
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For research use only. Not intended for any clinical use.

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