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Rabbit Anti-WNT6 Recombinant Antibody (BA0370) (CBMAB-0989CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0370
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide from residues in Human Wnt6
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Wnt family member 6
Introduction
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Entrez Gene ID
Human7475
Mouse22420
Rat316526
UniProt ID
HumanQ9Y6F9
MouseP22727
RatD4A3W9
Alternative Names
Wnt family member 6
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Biological Process
Biological Process axis specification Source:Ensembl
Biological Process branching involved in ureteric bud morphogenesis Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cornea development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process epithelial-mesenchymal cell signaling Source:Ensembl
Biological Process nephron tubule formation Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process odontogenesis of dentin-containing tooth Source:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcription Source:Ensembl
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of tooth mineralization Source:BHF-UCL1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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