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Rabbit Anti-WAPL Recombinant Antibody (D9J1U) (CBMAB-CP3006-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D9J1U
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human WAPL protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WAPL Cohesin Release Factor
Introduction
WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are Mitotic Telophase/Cytokinesis and CDK-mediated phosphorylation and removal of Cdc6.
Entrez Gene ID
Human23063
Mouse218914
Rat290577
UniProt ID
HumanQ7Z5K2
MouseQ65Z40
RatD4ADT3
Alternative Names
WAPL Cohesin Release Factor; KIAA0261; Friend Of EBNA2 Protein; WAPAL; FOE; Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2); Wings Apart-Like Homolog (Drosophila); Wings Apart-Like Protein Homolog; Friend Of EBNA2;
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process negative regulation of chromatin binding Source:UniProtKB2 Publications
Biological Process negative regulation of DNA replication Source:UniProtKB1 Publication
Biological Process negative regulation of sister chromatid cohesion Source:UniProtKB3 Publications
Biological Process protein localization to chromatin Source:UniProtKB1 Publication
Biological Process regulation of chromosome condensation Source:GO_Central1 Publication
Biological Process regulation of cohesin loading Source:UniProtKB1 Publication
Cellular Location
Isoform 2
Nucleus
Nucleus
Chromosome
Cytoplasm
Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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