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Mouse Anti-VPS53 Recombinant Antibody (H-4) (CBMAB-V0053-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
H-4
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
VPS53 GARP complex subunit
Introduction
VPS53 is a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi.
Entrez Gene ID
55275
UniProt ID
Q5VIR6
Alternative Names
VPS53, GARP Complex Subunit; Vacuolar Protein Sorting-Associated Protein 53 Homolog; Vacuolar Protein Sorting 53 Homolog (S. Cerevisiae); Vacuolar Protein Sorting 53 (Yeast); HVps53L; Pp13624; HCCS1; PCH2E
Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545).
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).
Biological Process
Biological Process endocytic recycling Source:UniProtKB1 Publication
Biological Process lysosomal transport Source:MGI1 Publication
Biological Process protein targeting to lysosome Source:Ensembl
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Biological Process vesicle-mediated cholesterol transport Source:Ensembl
Cellular Location
Golgi apparatus, trans-Golgi network membrane
Endosome membrane
Recycling endosome
Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061).
Involvement in disease
Pontocerebellar hypoplasia 2E (PCH2E):
An autosomal recessive neurodegenerative disorder characterized by progressive cerebello-cerebral atrophy, profound intellectual disability, progressive microcephaly, spasticity, and early-onset epilepsy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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