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Mouse Anti-VPS50 Recombinant Antibody (2D11) (CBMAB-C4857-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D11
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
VPS50, EARP/GARPII Complex Subunit
Entrez Gene ID
55610
UniProt ID
Q96JG6
Function
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Biological Process
Biological Process endocytic recycling Source:MGI1 Publication
Biological Process protein transport Source:UniProtKB-KW
Cellular Location
Recycling endosome
Membrane
Associates with membranes in an EIPR1-dependent manner.
Involvement in disease
Neurodevelopmental disorder with microcephaly, seizures, and neonatal cholestasis (NEDMSC):
An autosomal recessive disorder with onset at birth, characterized by severe global developmental delay, profoundly impaired intellectual development, progressive microcephaly, seizures, and transient neonatal cholestasis. Brain imaging shows agenesis or hypoplasia of the corpus callosum. Death in early childhood may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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