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Mouse Anti-VDAC3 Recombinant Antibody (1C6) (CBMAB-1447-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C6
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-283 from human VDAC3 (AAH56870) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
voltage-dependent anion channel 3
Introduction
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforMouse have been described for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
7419
UniProt ID
Q9Y277
Alternative Names
Voltage Dependent Anion Channel 3; Outer Mitochondrial Membrane Protein Porin 3; VDAC-3; Voltage-Dependent Anion-Selective Channel Protein 3; HD-VDAC3; HVDAC3;
Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Biological Process
Biological Process adenine transport Source:ProtInc1 Publication
Biological Process regulation of cilium assembly Source:InterPro
Cellular Location
Mitochondrion outer membrane
Membrane
May localize to non-mitochondrial membranes.
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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