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Mouse Anti-V-ATPase B2 Recombinant Antibody (CBYY-1827) (CBMAB-1308-YY)


See all V-ATPase B2 antibodies
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Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBYY-1827
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
V-ATPase B2
Function
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002).
V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091).
In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity).
Biological Process
Biological Process ATP metabolic process Source:InterPro
Biological Process proton transmembrane transport Source:ProtInc1 Publication
Biological Process regulation of macroautophagy Source:ParkinsonsUK-UCL1 Publication
Biological Process synaptic vesicle lumen acidification Source:Ensembl
Biological Process vacuolar acidification Source:GO_Central1 Publication
Cellular Location
Apical cell membrane
Melanosome
Cytoplasm
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cytoplasmic vesicle, clathrin-coated vesicle membrane
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Involvement in disease
Zimmermann-Laband syndrome 2 (ZLS2):
A form of Zimmermann-Laband syndrome, a rare developmental disorder characterized by facial dysmorphism with bulbous nose and thick floppy ears, gingival enlargement, hypoplasia or aplasia of terminal phalanges and nails, hypertrichosis, joint hyperextensibility, and hepatosplenomegaly. Some patients manifest intellectual disability with or without epilepsy. ZLS2 inheritance is autosomal dominant.
Deafness, congenital, with onychodystrophy, autosomal dominant (DDOD):
An autosomal dominant syndrome characterized mainly by congenital sensorineural hearing loss accompanied by dystrophic or absent nails. Coniform teeth, selective tooth agenesis, and hands and feet abnormalities are present in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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