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Mouse Anti-UPK3A Recombinant Antibody (IHC681) (CBMAB-MA259-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC681
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
Uroplakin 3A
Introduction
UPK3A is a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia.
Entrez Gene ID
7380
UniProt ID
O75631
Alternative Names
Uroplakin 3A; Uroplakin III; Uroplakin 3; UPIII; UP3A; UPK3; Uroplakin-3a; UPIIIA;
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
Biological Process
Biological Process cell morphogenesis Source:Ensembl
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process kidney development Source:Ensembl
Biological Process potassium ion homeostasis Source:Ensembl
Biological Process sodium ion homeostasis Source:Ensembl
Biological Process urea transport Source:GO_Central1 Publication
Biological Process urinary bladder development Source:Ensembl
Biological Process water transport Source:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum membrane
Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
Involvement in disease
Mutations in UPK3A have been detected in patients with renal adyplasia suggesting a possible involvement of this gene in kidney and urinary tract anomalies.
Topology
Lumenal: 19-207
Helical: 208-235
Cytoplasmic: 236-287
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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