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Mouse Anti-UNG Recombinant Antibody (1A6) (CBMAB-C4677-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A6
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human UNG produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5-1 mg/mL

Target

Full Name
uracil-DNA glycosylase
Introduction
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Entrez Gene ID
7374
UniProt ID
P13051
Alternative Names
Uracil DNA Glycosylase; Uracil-DNA Glycosylase 1, Uracil-DNA Glycosylase 2; UNG15; UNG1; DGU; UDG; Uracil-DNA Glycosylase;
Function
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Biological Process
Biological Process base-excision repair Source:HGNC1 Publication
Biological Process base-excision repair, AP site formation via deaminated base removal Source:UniProtKB1 Publication
Biological Process depyrimidination Source:Reactome
Biological Process DNA repair Source:ProtInc1 Publication
Biological Process isotype switching Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process somatic hypermutation of immunoglobulin genes Source:Ensembl
Cellular Location
Isoform 1
Mitochondrion
Isoform 2
Nucleus
Involvement in disease
Immunodeficiency with hyper-IgM 5 (HIGM5):
A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
PTM
Isoform 1 is processed by cleavage of a transit peptide.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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