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Mouse Anti-UNC13B (AA 418-1591) Recombinant Antibody (CBFYM-3177) (CBMAB-M3374-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3177
Antibody Isotype
IgG2b
Application
ELISA, IHC

Basic Information

Immunogen
Recombinant corresponding to aa418-1591 of human Munc13-2, expressed in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 5% trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 418-1591

Target

Full Name
Unc-13 Homolog B
Introduction
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
Entrez Gene ID
10497
UniProt ID
O14795
Alternative Names
Unc-13 Homolog B; Munc13-2; MUNC13; UNC13; Homolog Of Rat Munc13 (Diacylglycerol-Binding); Unc-13 Homolog B (C. Elegans)
Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity).
Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
Biological Process
Biological Process acrosomal vesicle exocytosis Source:UniProtKB1 Publication
Biological Process cellular response to glucose stimulus Source:ParkinsonsUK-UCL1 Publication
Biological Process chemical synaptic transmission Source:ParkinsonsUK-UCL
Biological Process dense core granule priming Source:GO_Central1 Publication
Biological Process neuromuscular junction development Source:GO_Central1 Publication
Biological Process neuronal dense core vesicle exocytosis Source:UniProtKB
Biological Process positive regulation of apoptotic process Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of inhibitory postsynaptic potential Source:ParkinsonsUK-UCL
Biological Process positive regulation of protein secretion Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of synaptic vesicle priming Source:ParkinsonsUK-UCL
Biological Process presynaptic dense core vesicle exocytosis Source:GO_Central1 Publication
Biological Process synaptic transmission, glutamatergic Source:GO_Central1 Publication
Biological Process synaptic vesicle docking Source:GO_Central1 Publication
Biological Process synaptic vesicle maturation Source:GO_Central1 Publication
Biological Process synaptic vesicle priming Source:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
Membrane
Cell membrane
Synapse
Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).
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For research use only. Not intended for any clinical use.

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