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Mouse Anti-UBE4A Recombinant Antibody (CBFYU-175) (CBMAB-U0175-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-175
Antibody Isotype
IgG2a, к
Application
ELISA, ELISA(Cap), IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitination factor E4A (UFD2 homolog, yeast)
Introduction
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin.
Entrez Gene ID
9354
UniProt ID
Q14139
Alternative Names
E4; UFD2; UBOX2
Function
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
Biological Process
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication
Cellular Location
Cytoplasm
Involvement in disease
Neurodevelopmental disorder with hypotonia and gross motor and speech delay (NEDHMS):
An autosomal recessive disorder characterized by severe global developmental delay apparent from infancy, axial hypotonia, limited or absent ability to walk, impaired intellectual development, and poor or absent speech. Additional features may include seizures, behavioral problems, distal skeletal anomalies, and facial dysmorphism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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