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Mouse Anti-UBE2M Recombinant Antibody (CBFYU-135) (CBMAB-U0135-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Dog
Clone
CBFYU-135
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human UBE2M(NP_003960) produced in HEK293T cell
Specificity
Human, Mouse, Dog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.69 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
UBE2M
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. Diseases associated with UBE2M include Familial Hypertension. Among its related pathways are Protein ubiquitination and Class I MHC mediated antigen processing and presentation.
Entrez Gene ID
Human9040
Mouse22192
Dog484221
UniProt ID
HumanP61081
MouseP61082
DogA0A8C0RW57
Alternative Names
UBC12; hUbc12; UBC-RS2
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Biological Process
Biological Process positive regulation of neuron apoptotic process Source:Ensembl
Biological Process post-translational protein modification Source:Reactome
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
PTM
The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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