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Mouse Anti-UBE2L6 Antibody (12BA34) (CBMAB-1709CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
12BA34
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 L6
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins and functions in the E6/E6-AP-induced ubiquitination of p53/TP53. It may promote ubiquitination and subsequent proteasomal degradation of FLT3. Among its related pathways are Proteolysis_Putative ubiquitin pathway and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.
Entrez Gene ID
9246
UniProt ID
O14933
Alternative Names
ubiquitin-conjugating enzyme E2L 6; UBCH8; Retinoic acid-induced gene B protein; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; RIG-B; EC 6.3.2.19; retinoic acid induced gene B protein; ubiquitin/ISG15-conjugating enzyme E2 L6; UbcH8
Function
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
Biological Process
Biological Process ISG15-protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
ubiquitin ligase complex
PTM
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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