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Rabbit Anti-TXNRD1 Recombinant Antibody (D1T3D) (CBMAB-CP2880-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Monkey
Clone
D1T3D
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly412 of human TRXR1 protein.
Specificity
Human, Mouse, Rat, Hamster, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TXNRD1 Gene(Protein Coding) Thioredoxin Reductase 1
Introduction
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
Entrez Gene ID
Human7296
Mouse50493
Rat58819
Monkey701062
Hamster100771594
UniProt ID
HumanQ16881
MouseQ9JMH6
RatO89049
MonkeyH9H3J3
HamsterA0A1U7QYQ1
Alternative Names
Thioredoxin Reductase 1; Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein; KM-102-Derived Reductase-Like Factor; Thioredoxin Reductase TR1; EC 1.8.1.9; GRIM-12; TR; Testis Tissue Sperm-Binding Protein Li 46a; Thioredoxin Reductase 1; Cytoplasmic;
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Biological Process
Biological Process cell population proliferation Source:Ensembl
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm
PTM
Isoform 5
The N-terminus is blocked.
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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