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Mouse Anti-TRMT112 Recombinant Antibody (CBYJT-4868) (CBMAB-T4414-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4868
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-126 from human HSPC152 (AAH17172) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-126

Target

Full Name
TRNA Methyltransferase Subunit 11-2
Introduction
TRMT112 (TRNA Methyltransferase Subunit 11-2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and Gene Expression. Gene Ontology (GO) annotations related to TRMT112 include protein methyltransferase activity.
Entrez Gene ID
51504
UniProt ID
Q9UI30
Alternative Names
TRNA Methyltransferase Subunit 11-2; TRNA Methyltransferase 112 Homolog; Multifunctional Methyltransferase Subunit TRM112-Like Protein; TRNA Methyltransferase 11-2 Homolog (S. Cerevisiae); TRNA Methyltransferase 11-2 Homolog; TRM112-Like Protein
Function
Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604, PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31328227, PubMed:31636962, PubMed:31061526).
Together with methyltransferase BUD23, methylates the N7 position of a guanine in 18S rRNA (PubMed:25851604).
The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31636962, PubMed:31061526).
The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526).
The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323).
Together with methyltransferase THUMPD3, catalyzes the formation of N2-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960).
Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).
Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:33428944, PubMed:35033535, PubMed:31328227).
Biological Process
Biological Process histone lysine methylation Source:UniProtKB1 Publication
Biological Process peptidyl-glutamine methylation Source:UniProtKB2 Publications
Biological Process positive regulation of rRNA processing Source:UniProtKB1 Publication
Biological Process rRNA (guanine-N7)-methylation Source:UniProtKB1 Publication
Biological Process rRNA methylation Source:UniProtKB2 Publications
Biological Process tRNA methylation Source:GO_Central1 Publication
Biological Process tRNA N2-guanine methylation Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleoplasm
Cytoplasm, perinuclear region
Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604).
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For research use only. Not intended for any clinical use.

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